Plasma transfusions are indicated in complex coagulopathy and isolated factor deficiencies when factor concentrates are not available. Such conditions include, amongst others, disseminated intravascular coagulation, bleeding in parenchymal liver disease with evidence of coagulopathy, thrombotic thrombocytopenic purpura (TTP, substitution of vWF:CP = ADAMTS13), factor V and XI deficiencies, as well as blood loss/dilution coagulopathy resulting from surgery or trauma.
Nowadays trauma is the main cause of death in individuals aged between 18 and 40 years. In recent years, surveys have found that up to 34 % of patients injured in accidents or military conflict are admitted with clinically significant acute coagulopathy and that they ran a significantly (up to four times) higher risk of mortality compared to patients without coagulopathy (Pidcoke et al., MacLeod et al.).
Early transfusion of plasma (Gonzales et al.) is therefore recommended for trauma patients, despite the fact that such an approach is still hotly debated (Murad et al.) .
Increased plasma ratios (plasma to red blood cell ratios and plasma to platelet concentrate ratios of 1:1 or more) in the early stage of first-line treatment correlate with a lower mortality rate in patients who have received 3 or more units of blood components within 24 hours of admission to hospital.
The use of LyoPlas N - w is not indicated as a volume, protein or albumin substitute, for immunoglobulin substitution or as parenteral nutrition (Cross-sectional guidelines for therapy with blood components and plasma derivatives).
The plasma for each unit of LyoPlas N - w is derived from a single donation. LyoPlas N - w may be stored in a refrigerator or at room temperature, i.e. at a temperature range of +2°C to +25°C. It is used in the same indications as conventional fresh frozen plasma. It takes only a few minutes to dissolve the freeze-dried plasma in the supplied water for injection - making it readily available when needed.
Please read the package leaflet and ask your doctor or pharmacist about potential risks and side effects.